someone else online summarized the genetics part as the following:
Mandelian randomisation studies show that LDL-c is causative in atherogenic plaques 1 and metabolic ward RCTs show that SFA intakes increase LDL-c, while the decrease in SFAs lead to lower total and LDL-c 2.
But yes, almost all nutrition science is a bit inconclusive because of genetic variation.
Forgive me, because I’m struggling to understand the linked information, but as someone with atherosclerosis this is an issue close to my heart (ha!).
I just want to make sure I understand you.
Your link to the european heart journal says that the causal link between LDL and ASCVD is “unequivocal”.
I think the WHO study says (amongst a lot of other complicated stuff) that replacing SFAs with PUFAs and MUFAs is more favourable than replacing SFAs with complex carbohydrates? The strong implication being (although I couldn’t see this exactly) that higher SFA intake contributes to heart disease.
effects on the serum lipoprotein profile
of reducing SFA intake by replacing a mixture of SFA with cis-PUFA […] or cis-MUFA […] were more favourable than replacing SFA with a mixture of carbohydrates.
not just genetics, wasnt there a tokyo study recently linking metabolism to the time of your conceiving? i.e. colder climates equals to slimmer people, whereas a hot climate is breeding grounds for obesity
WHO report
someone else online summarized the genetics part as the following:
Forgive me, because I’m struggling to understand the linked information, but as someone with atherosclerosis this is an issue close to my heart (ha!).
I just want to make sure I understand you.
Your link to the european heart journal says that the causal link between LDL and ASCVD is “unequivocal”.
I think the WHO study says (amongst a lot of other complicated stuff) that replacing SFAs with PUFAs and MUFAs is more favourable than replacing SFAs with complex carbohydrates? The strong implication being (although I couldn’t see this exactly) that higher SFA intake contributes to heart disease.
I don’t think it tries to compare carbohydrates to any UFAs, but the implication is indeed that SFAs significantly contribute to heart disease.
Ah, thanks, I’ve missed that.
not just genetics, wasnt there a tokyo study recently linking metabolism to the time of your conceiving? i.e. colder climates equals to slimmer people, whereas a hot climate is breeding grounds for obesity