It only makes prodrugs that first need to be metabolized by CYP3A4 to be active less effective. This is a pretty small minority of drugs. It makes drugs that are inactivated by CYP3A4 more effective, which is the majority of them. It also only competitively inhibits the enzyme while the drug is in your system, it’s not permanently inhibiting the enzyme like a suicide inhibitor.

Eat more good food and lift some weights to gain muscle mass. You don’t have to be one of those giant dudes but a bit of definition goes a long way. It’ll also help prevent you from being frail when you’re older. I’d like to continue opening jars and carrying my own groceries for as long as possible. There are a lot of health benefits, and you don’t even need to go to the gym if you get adjustable weights and a multipurpose bench. I’ve been doing exactly this and I’m up 40 lbs and look better. I’m still a tall lanky dude at 6’3”, but I’m not nearly as skinny (165->205lbs).

Ah, fair enough. I see that’s likely the case now.

Reddit is winning over advertisers by showing that it’s different than other internet platforms, which often rely on users’ identities and personal information to target ads. Instead, Reddit is targeting people based on their interests, relying on the site’s deeply detailed communities — called subreddits — to match advertisers with potential customers.

Knowing which subreddits I’m following IS using my data, assholes.

Edit: I’m probably wrong about what they’re doing, see below.

It’s broader than just a Disney+ trial account, it’s part of the whole Disney account, such as when you buy tickets as he did in 2023. Between that and the Florida judge I’m not sure it will get thrown out.

Best case scenario is forced arbitration is just ended. It should be an option, not a requirement.

https://www.bbc.com/news/articles/c8jl0ekjr0go

Disney adds that Mr Piccolo accepted these terms again when using his Disney account to buy tickets for the theme park in 2023.

By no means do I agree with forced arbitration, but so many articles are reporting this partially.

They also agreed to the same clause when buying the tickets in 2023. It’s not just the streaming service ToS in play. Sure gets a lot of clicks saying it like it was though.

Again I think this is all horseshit and forced arbitration can get fucked, but it’s not being reported properly. The Disney+ trial could have not happened at all and the argument from Disney wouldn’t change.

https://www.bbc.com/news/articles/c8jl0ekjr0go

Disney adds that Mr Piccolo accepted these terms again when using his Disney account to buy tickets for the theme park in 2023.

You’re absolutely going to lose weight at 500-1000 kcal a day. It’s not particularly healthy, and you’re going to lose significant muscle mass, but you will absolutely lose weight rapidly. A significant caloric deficit will not prevent weight loss; its thermodynamics. You’ll lose muscle with that much of a deficit, which in turn decreases basal metabolic rate, but you’re not going to violate thermodynamics.

How are you tracking intake? If you’re not losing weight, I don’t believe you’re tracking calories correctly. Are you using a scale and weighing portions, or just eyeballing it?

It’s not about the degree of genetic hybridization but rather what’s playable. 100% dragon MMO means there’s only dragons, no other playable creatures. Pretty straightforward, no?

Regarding the testing - Short of waiting 100 years, how else would you accelerate the degradation of the discs to simulate aging?

Not totally surprised about Reddit falling for some misunderstood labeling. Just curious about that, mainly.

However, even if they are perfect they still wouldn’t meet my needs. I couldn’t use them to share data with anyone I know, as nobody has a data Blu-ray drive. I can’t access the data on them at a whim, and they’re slower than a RAID array. I can’t easily perform automated routine data scrubbing to ensure corruption hasn’t occurred. Speaking of; how often do you verify the data on your discs, and how do you do it?

I can see its usefulness in some scenarios (cold storage), but I’m quite happy with my NAS.

Are those the m-disc? I’ve heard they’re no longer using the inorganic layer you’re referring to, but still being sold with the same branding.

https://www.reddit.com/r/DataHoarder/comments/yu4j1u/psa_verbatim_no_longer_sells_real_m_discs_now/

For me, it’s just too much risk. I don’t want to have to worry about counterfeit discs or a silent downgrade from the manufacturer. Those inorganic discs are slated to last a long time, but who really knows? A set of HDDs in RAID with a 3-2-1 backup strategy is the gold standard. HDDs do fail, and I’ve already planned for that.

You do point out some good points I didn’t consider before for BD-R, but for me, it’s NAS and sneakernet with flash drives for the homies. Hardly anyone I know has an optical drive anymore, much less a Blu-ray drive in their PC.

Building a NAS is a large upfront cost but it’s worth it IMO. Giant HDDs are fairly cheap now and you can use cool filesystems like Btrfs to combat bit flips from cosmic rays and the like. I’m not sure I’d trust a dye based optical media, but there are apparently some archive quality 100 year BD-R. Most have a drastically shorter lifespan, though.

According to the Canadian Conservation Institute, which publishes a paper on media longevity, BD-R discs are expected to last between 5 and 20 years, depending on the material they are made out of. BD-RE, which is erasable Blu-ray, is estimated for 20 to 50 years while DVD-R and CD-R, which hold a lot less data, can last 50 to 100 years.

https://www.tomshardware.com/news/pioneer-new-blu-ray-recorder-and-bdr-promise-100-years-lifespan

Don’t forget the fault lines

What do you mean by channel, like on Telegram?

This is a region specific Telegram setting if so, it’s not iOS. Tell her to disable the adult content filter.

my girlfriend has iOS, and every time I want to forward an nsfw gif she doesn’t see it

Say what? There’s no content censoring that I’m aware of. I’ve had no issues looking at all kinds of NSFW/NSFL content.

Regardless, you’re likely not going to enjoy the lack of modified apps and game piracy; I don’t do either of those. Maybe it’s possible but you’ve gotta jump through so many hoops IMO it wouldn’t be worth it.

Zero issues with NSFW though, that’s bizarre to me. There’s screen time web content filtering but I believe that only affects safari.

On your map most of Long Island is unaffected. It’s 12km moderate blast damage (5 psi) from the Chinese nuke. Long Island goes way off to the east. It’s 190km long.

Tsar bomba is a different story though.

I’ve not come across anything that’s OLED unfriendly. I’m not sure what you mean to be honest.

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Webrips aren’t as good as web-dls though. You can find web-dl fairly easily via torrent.

Is this the correct community for this post? Doesn’t seem too piracy related to me.

I like MeGusta, ELiTE, and NTb.